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Index > Protein center > MMP19(Gene name) > Human
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  • MMP19 (Gene name),
  • Matrix metalloproteinase-19 (Protein name ),  MMP19_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    MMP19(MMP18;RASI);
    Protein name:
    Matrix metalloproteinase-19(MMP-19);
    Alternative:
    Matrix metalloproteinase-18(MMP-18);Matrix metalloproteinase RASI;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.
    Subcellular Location:
    Secreted extracellular space extracellular matrix
    Protein Attributes:
    Sequence length:
    508
    Sequence:
    50:
    MNCQQLWLGF | LLPMTVSGRV | LGLAEVAPVD | YLSQYGYLQK | PLEGSNNFKP | 
    100:
    EDITEALRAF | QEASELPVSG | QLDDATRARM | RQPRCGLEDP | FNQKTLKYLL | 
    150:
    LGRWRKKHLT | FRILNLPSTL | PPHTARAALR | QAFQDWSNVA | PLTFQEVQAG | 
    200:
    AADIRLSFHG | RQSSYCSNTF | DGPGRVLAHA | DIPELGSVHF | DEDEFWTEGT | 
    250:
    YRGVNLRIIA | AHEVGHALGL | GHSRYSQALM | APVYEGYRPH | FKLHPDDVAG | 
    300:
    IQALYGKKSP | VIRDEEEEET | ELPTVPPVPT | EPSPMPDPCS | SELDAMMLGP | 
    350:
    RGKTYAFKGD | YVWTVSDSGP | GPLFRVSALW | EGLPGNLDAA | VYSPRTQWIH | 
    400:
    FFKGDKVWRY | INFKMSPGFP | KKLNRVEPNL | DAALYWPLNQ | KVFLFKGSGY | 
    450:
    WQWDELARTD | FSSYPKPIKG | LFTGVPNQPS | AAMSWQDGRV | YFFKGKVYWR | 
    500:
    LNQQLRVEKG | YPRNISHNWM | HCRPRTIDTT | PSGGNTTPSG | TGITLDTTLS | 
    508:
    ATETTFEY
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    MIM:
    String:
    UniGene:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human MMP-19
    Cat.:
    E1489h
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human MMP-19
    Cat.:
    E1489m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human MMP-19
    Cat.:
    U1489h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human MMP-19
    Cat.:
    U1489m
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human MMP-19
    Cat.:
    P1489Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human MMP-19
    Cat.:
    P1489Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human MMP-19
    Monoclonal Antibody for Human MMP-19
    Protein for Human MMP-19
    Protein for Human MMP-19

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Identification of MMP-18, a putative novel human matrix metalloproteinase."
      Cossins J. , Dudgeon T.J. , Catlin G. , Gearing A.J.H. , Clements J.M.
      Biochem. Biophys. Res. Commun.228:494-498(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Mammary gland.
    2. 2.
      "Identification and characterization of a novel human matrix metalloproteinase with unique structural characteristics, chromosomal location and tissue distribution."
      Pendas A.M. , Knaeuper V.V. , Puente X.S. , Llano E. , Mattei M.-G. , Apte S. , Murphy G. , Lopez-Otin C.
      J. Biol. Chem.272:4281-4286(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Liver.
    3. 3.
      "The matrix metalloproteinase RASI-1 is expressed in synovial blood vessels of a rheumatoid arthritis patient."
      Kolb C. , Mauch S. , Peter H.-H. , Krawinkel U. , Sedlacek R.
      Immunol. Lett.57:83-88(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Rheumatoid arthritic synovial fluid.
    4. 4.
      "Matrix metalloproteinase MMP-19 (RASI-1) is expressed on the surface of activated peripheral blood mononuclear cells and is detected as an autoantigen in rheumatoid arthritis."
      Sedlacek R. , Mauch S. , Kolb B. , Schaetzlein C. , Eibel H. , Peter H.-H. , Schmitt J. , Krawinkel U.
      Immunobiology198:408-423(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Rheumatoid arthritic synovial fluid.
    5. 5.
      Mauch S. , Sedlacek R. , Krawinkel U. , Schaetzlein C.
      Submitted (1995-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3)
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
      tissue: Thymus.
    7. 7.
      NIEHS SNPs program
      Submitted (2004-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS CYS-103; THR-488 AND MET-491
    8. 8.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    10. 10.
      "Biochemical characterization of the catalytic domain of human matrix metalloproteinase 19. Evidence for a role as a potent basement membrane degrading enzyme."
      Stracke J.O. , Hutton M. , Stewart M. , Pendas A.M. , Smith B. , Lopez-Otin C. , Murphy G. , Knaeuper V.
      J. Biol. Chem.275:14809-14816(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF N-TERMINUS;FUNCTION;MUTAGENESIS
    11. 11.
      "Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP)."
      Stracke J.O. , Fosang A.J. , Last K. , Mercuri F.A. , Pendas A.M. , Llano E. , Perris R. , Di Cesare P.E. , Murphy G. , Knaeuper V.
      FEBS Lett.478:52-56(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION
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